4/16/2024 0 Comments Barnes noble collectible editions![]() Good for US buyers but international shipping is usually not available or it’s cost prohibitive.ĭymocks (Australia) have a few exclusive editions. Good for US buyers but international shipping is often not available or may be cost prohibitive.īooksAMillion (US) have a few exclusive editions. Target(US) have a few exclusive editions. International shipping may be cost prohibitive. Indigo (Canada) have lots of signed editions and exclusive content, often replicating the B&N editions. Usually no tracking number is provided, but lovely customer service. I’ve got some lovely Independent bookstore editions from here. Good for UK buyers but international shipping is expensive.īlackwells (UK) sometimes have signed editions, and international shipping is included in the price of the book. The Broken Binding (UK) make beautiful exclusive sprayed edge editions of fantasy and horror books. Good for UK buyers but international shipping is expensive. Customer service used to be excellent, but as of 2023 there is often a long delay if you are trying to contact them by email. The number of exclusive edition copies produced ranges between a few hundred and a thousand, and they are usually numbered. As a bonus, all their books are hand covered with protective dust jackets and they come incredibly well wrapped. Goldsboro Books (UK) have special limited editions, sprayed edges and a couple of excellent book subscription programs (see below). There are typically a few thousand copies of their exclusive editions. They are a good store for US-based buyers, but it’s a bit hit and miss if they will ship books internationally – some books they will, some they won’t. There are typically between 1000-2000 copies of their exclusive editions produced.īarnes and Noble (US) have lots of signed editions, which often include exclusive content and different dust jacket designs. They ship internationally – it’s quite expensive for a single book, but if you’re buying a few shipping becomes really reasonable (only £ 1 extra per book, even if they are preorders!), and they send you a tracking number. Waterstones (UK) have lots of signed editions, which often include sprayed edges and exclusive content. There are a few stores that regularly release produce special editions, and you can visit their sites to see what they have available. Please feel free to send me details of any books you think should be added to the list ツ The bottom of this page has some suggestions for bookshops and subscription boxes that create their own special editions where you may be able to purchase individual titles, as well as a list of artists that create custom stencilled edges. However, many of these earlier titles are still available (and desirable!), so it’s definitely worth taking a look through the archives as well. Recent special editions remain on this page for a few months, while older editions are archived to make the page length more manageable. Feel free to bookmark and visit regularly to see what’s new, or subscribe for the occasional email update!ĭetails are based on publisher notices and may change before publication. I update this page every week or two with upcoming preorders and recent releases of special edition books that anyone can purchase – and you can even frequently get a preorder discount if you’re early enough to buy. Where do people find these gems, you wonder? Maybe they talk about getting them through exclusive (albeit expensive) book clubs like Illumicrate or FairyLoot, or maybe they are investing in beautiful (although yet again, expensive) publishers like Folio Society or Easton Press.īut what if you want some of these special editions for your own book collection – books with sprayed edges, beautiful designs, limited editions – without the sort of serious financial commitment of a subscription or fine press edition – how can you get them? Well, I’m glad you asked, because I’m here to help! About this list Once you’ve started building up an an interesting book collection, you’re bound to start noticing special editions on other peoples shelves. How do I find exclusive, special and limited edition books? Advice from a long-time collector.
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![]() Object itself, its _as_parameter_ attribute, or whatever you want to Whatever is needed to make sure this object is acceptable, and then return the The Python object passed to the function call, it should do a typecheck or To implement a from_param() class method for them to be able to use them If you have defined your own classes which you pass to function calls, you have > printf ( b " %d %d %d ", 1, 2, 3 ) Traceback (most recent call last):įile "", line 1, in ArgumentError: argument 2: TypeError: wrong type > printf ( b " %s %d %f \n ", b "X", 2, 3 ) X 2 3.000000 13 > Sys.stdout, so these examples will only work at the console prompt, not Note that printf prints to the real standard output channel, not to To create a mutable memoryīlock containing unicode characters of the C type wchar_t, use theĬreate_unicode_buffer() function. The create_string_buffer() function replaces the old c_buffer()įunction (which is still available as an alias). value = b "Hi" > print ( sizeof ( p ), repr ( p. value )) b'Hello' > p = create_string_buffer ( b "Hello", 10 ) # create a 10 byte buffer > print ( sizeof ( p ), repr ( p. raw )) 6 b'Hello\x00' > print ( repr ( p. raw )) 3 b'\x00\x00\x00' > p = create_string_buffer ( b "Hello" ) # create a buffer containing a NUL terminated string > print ( sizeof ( p ), repr ( p. > from ctypes import * > p = create_string_buffer ( 3 ) # create a 3 byte buffer, initialized to NUL bytes > print ( sizeof ( p ), repr ( p. ![]() The constructor accepts any object with a truth value.Īll these types can be created by calling them with an optional initializer of Fundamental data types ¶Ĭtypes defines a number of primitive C compatible data types: Int type, their value is masked to fit into the C type.īefore we move on calling functions with other parameter types, we have to learn Python integers are passed as the platforms default C None is passed as a C NULL pointer, bytes objects and strings are passedĪs pointer to the memory block that contains their data ( char * or ![]() Python objects that can directly be used as parameters in these function calls. None, integers, bytes objects and (unicode) strings are the only native from segmentation faults produced by erroneous C library The faulthandler module can be helpful inĭebugging crashes (e.g. There are, however, enough ways to crash Python with ctypes, so you ![]() GetModuleHandleA ( 32 ) Traceback (most recent call last):įile "", line 1, in OSError: exception: access violation reading 0x00000020 > The errorĬode is used to automatically raise an OSError exception when the oledll also uses the stdcall calling convention, andĪssumes the functions return a Windows HRESULT error code. Loads libraries which export functions using the standard cdecl callingĬonvention, while windll libraries call functions using the stdcallĬalling convention. You load libraries by accessing them as attributes of these objects. Objects, for loading dynamic link libraries. Loading dynamic link libraries ¶Ĭtypes exports the cdll, and on Windows windll and oledll So, you should not be confused if c_long is printed if you would expectĬ_int - they are actually the same type. Where sizeof(long) = sizeof(int) it is an alias to c_long. Note: Some code samples reference the ctypes c_int type. Windows, or macOS, they contain doctest directives in comments. Since some code samples behave differently under Linux, Note: The code samples in this tutorial use doctest to make sure that Used to wrap these libraries in pure Python. It provides C compatibleĭata types, and allows calling functions in DLLs or shared libraries. Ctypes - A foreign function library for Python ¶Ĭtypes is a foreign function library for Python. 4/16/2024 0 Comments Download gta 5 free pcThis can be done either through Parallels or Boot Camp, as is shown in the guides below. To download GTA 5 on Mac, you must have Windows installed on the computer. Make sure that DXVK is enabled, then launch and log into Steam, find the game in your library, install it, and click Play. Then open the Steam bottle’s C: drive, go to windows > system32 and copy-paste everything from the ZIP file’s 圆4 folder into the system32 folder.ĥ. Download the latest DXVK version from here, open the ZIP file and go to the 圆4 folder. Right-click the newly-created bottle, click Install Software in Bottle, and then search for and install Steam (or another game launcher if you own the game elsewhere).Ĥ. Open CrossOver and create a new Bottle from the Bottle menu.ģ. Update your macOS to macOS Sonoma, visit the CrossOver site by clicking the button below, and download and install CrossOver.Ģ. You may need to find the game in your personal library – do that, click Play, and the game will start inside the browser.īoosteroid runs perfectly fine through browsers like Chrome and Firefox (the Safari experience can be a bit janky), but if you want, you can also try using the service through the Boosteroid client for Mac, which you can download for free from the service’s site.ġ. Depending on the chosen version, you will need to log in to your Steam/Epic Games/Rockstar account to Boosteroid.ħ. Click on the Install and Play button and then select Ok, let’s go if you get a prompt.Ħ. Select a subscription plan and provide the necessary payment details.ĥ. Click on your new account’s name in the upper right corner of your screen to view the available subscription options.ģ. Go to the Boosteroid website and follow the steps to create an account, or simply sign up with your Google account (we recommend this).Ģ. Methods like Game Porting Toolkit or Crossover will not give you a good experience in general and will drain your battery fast.ġ. We recommend starting with Boosteroid, then switching to GFN later if you feel like it. GeForce Now is a higher-value alternative, but to achieve better results than Boosteroid, the service wants 6-month payments to subscribe to its highest tier. It requires only a good internet connection. It provides fast support for new big titles, hits a constant high performance level (60 FPS) that’s rarely achievable except for native mac ports, and with graphics options reserved for high-end PCs. Why we recommend Boosteroid over the other methodsīoosteroid has the best ‘bang for buck’ of all methods. Play GTA 5 on Mac with Boosteroid Recommended Method Update: Limited time offer now available at, buy GTA V Premium Edition -84% Off for $10.99 (RockStar Launcher) If you choose to play GTA 5 with Cloud Gaming trough Boosteroid, we recommend testing the speed and latency of your Internet through the built-in tool on the service’s website.īefore playing GTA V make sure you have a Steam, Epic Games, or Rockstar compatible version of the game. You can game with Boosteroid on any Mac (Intel, Apple Silicon), so long as the machine can run a browser and you have a decent Internet connection. ![]() Currently, the only game streaming platform that features this title in its library is Boosteroid, and we’ll show you how to use it. To play GTA 5 with cloud gaming, you need to subscribe to a cloud gaming service that supports the game. Those will allow you to install the Windows version of GTA V on your Mac and play the game locally, but those methods are significantly more demanding on the computer and take more time to set up. ![]() If you are not a fan of cloud gaming or if your Internet isn’t good enough to get a decent streaming quality, the alternative is to try using apps like Parallels or Boot Camp. Also, the specs of your machine will be irrelevant and won’t impact the game’s performance, whether you are playing GTA 5 on an M1 Mac or an Intel Mac. ![]() With this method, you won’t even need to install the game and dedicate a ton of storage space to it. To play GTA V on Mac, our recommendation is to use a game-streaming service that supports the game, like the one we’ve included later in this article. Obviously, none of these methods are perfect, but they can still get you pretty close to the experience of playing the game on a Windows PC machine. The other options to play GTA 5 on Mac are to install or emulate Windows, or to use a compatibility layer.ĭespite the lack of a macOS version for this game, there’s clearly no shortage of useful workarounds that can still let you enjoy it on a Mac computer. The cloud gaming method is the easiest one to set up and can be used on any Mac – we’ll show you how further down this post. You can totally play GTA 5 on Mac, but you’ll need to use a workaround method such as cloud gaming or Windows emulation. 4/16/2024 0 Comments Downloadable freecell gameWhen the deck is exhausted, click it again to replenish it from the cards in the waste. Click the deck to transfer three cards to the wastepile, the top of which is playable. However, only Kings can fill empty columns. The tableaus are built downwards by rank and alternatioing color, and faceup piles of any length can be moved. The game is won when all the foundations are built in up rank and suit from Ace to King. Klondike is the most popular solitaire game, so much so that the word �solitaire� immediately brings to mind this specific game. Klondike Solitaire Rules (Patience, Fascination) You'll be winning Canfield solitaire in no time! If you can manage this, then play the waste pile carefully by only moving out cards that open additional moves or let you free tableau spaces. Due to the lax movement rules and the fact that relatively few cards start off unavailable, a good winning strategy for this solitaire is to card on getting all cards from the reserve in play as soon as possible. Once the deck is exhausted, click it to move all the cards from the waste back to the deck again. The top card in the waste and the reserve are always available to play on the foundation or tableau. If no more moves are avaible, click the deck to deal three cards to the waste pile. ![]() If the reserve is empty, any card or pile can be moved to a free slot. When you created a free slot, the top card from the reserve, if available, automatically fills it. Build the tableau by playing cards of descending rank and alternating color moves of partial or full stacks are also allowed. Build the rest of the foundations up by suit according to this cards rank. At first one card is delt from the deck to the first foundation. Since the foundation starts of with one card and many cards are exposed for play at once, Agnes is a game that allows for much more skill and higher odds of winning than its more popular parent.Ĭanfield is a solitaire game that was originally created to be nearly unwinnable, but due to people easing the rules over the years, it can now often be won with a bit of skill. When the deck is down to two last cards, they're transferred to the normal wastepile and both are available to play. The top card of each reserve can be played on the foundations or the tableau empty reserve slots will remain empty until the next deal. The other difference is how the deck is dealt click the top of the deck to deal one card to each of the seven reserve piles. Free tableau spaces can be filled by any card or pile starting with a card that's one less than the foundation seed. Ranks in this game wrap around, so a king or pile starting with a king can be played on an ace. The tableau piles are built the same as in Klondike, down by suit and in alternating colors. The first difference between Agnes and Klondike is that the top of the deck is dealt to the first foundation the rest of the foundations are built up by suit starting with this card's rank. However, its rules are changed to make the odds of winning the game easier. When the installation is finished you should be able to see and run the program.Agnes is member of the ever-famous Klondike solitaire family.Once the Free FreeCell Solitaire is downloaded click on it to start the setup process (assuming you are on a desktop computer).This will start the download from the website of the developer. Click on the Download button on our website.How to install Free FreeCell Solitaire on your Windows device: Your antivirus may detect the Free FreeCell Solitaire as malware if the download link is broken. We have already checked if the download link is safe, however for your own protection we recommend that you scan the downloaded software with your antivirus. ![]() The program is listed on our website since and was downloaded 5934 times. ![]() Just click the green Download button above to start the downloading process. ![]() The download we have available for Free FreeCell Solitaire has a file size of 7.34 MB. This version was rated by 9 users of our site and has an average rating of 3.0. The latest version released by its developer is 3.1. The company that develops Free FreeCell Solitaire is. Free FreeCell Solitaire is compatible with the following operating systems: Windows. This Card Games program is available in English. Free FreeCell Solitaire is a free software published in the Card Games list of programs, part of Games & Entertainment. ![]() Download for Free Choosing a template before creating a goal for your infographic can speed up your infographic creation process. Start using our infographics Google Slides Themes and PowerPoint templates today and bring your information to life in a creative and engaging way. As you saw pictured above, you can download our 15 infographic templates in PowerPoint and choose whichever template you'd like. The best part is, our templates are easy to use and customize. 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A two-color design choice of light or dark including charts, maps, diagrams, and other useful slides for multipurpose presentations. ![]() If you want, you may check our other free PowerPoint templates as well.Do you want to make your presentations more engaging and visually appealing? Look no further than our collection of infographics presentation templates! Infographics are special because they use pictures, icons, and symbols to present information in a clear and fun way. Free Modern Business Powerpoint Template. As we are providing this PowerPoint presentation slide for free, we may expect your kind piece of support for our work. This infographic PowerPoint slide can be used for any sort of presentation but especially to explain any steps or process, it will suit the best. Please, watch the tutorial video to have a clear idea regarding the whole process. There are 30 unique slides included in this template that are perfect for tech startup and business presentations. 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If you need to present your data in a visual way and to compare different items, banner infographics are simply perfect for you. Step 02 Setting custom shadowīefore using the shadow on the shape, make sure you have changed its color and removed the outline. Free Google Slides theme and PowerPoint template. Téléchargez le modèle Infographies - Recherche sur les films dystopiques pour PowerPoint ou Google Slides et découvrez la puissance des infographies. Then, holding the ctrl button select these two shapes, go to format, and from merge shape select subtract. After that pick an oval shape, holding the ctrl+shift drag it in the top middle of the previously added rectangle. Step 01 Add a few shapesĪt first, you have to add a top corner rounded rectangle and then rotate vertically. Please, remember that for this PowerPoint template, I have used the light gray color in the slide background. At first, you need to create the infographic and then you can add the proper animations on them. Here, we have proper written documentation where we have discussed the step-by-step process in brief. Download this Template for Free Information about this template 4/16/2024 0 Comments Yamaha bolt after ecu flashI have this mod ad will give the details. On a side note, he actually offered to give me further explanation of his service to specific questions i had, which i sent him, and then never heard from him again.īonus points if anyone can explain the following from his site for the 950 model:Ī) Gets rid of part throttle timing retarder for more response and less vibration when cruising and moderate acceleration.ī) Gets rid of high rpm timing retarder allowing the engine to make maximum power for longer.Ĭ) Set timing for maximium power and driveability across the entire rpm range & all throttle positions"Īre all these just the effects from the single action of raising the rev limit of each gear? i could go on and on about the new questions that are raised with the new info he's put up, but that road hasn't gone anywhere. and since he fine tunes each person's ECU to their specific setup (air/exhaust mods), i was hoping Cipher could answer what was specifically, or even vaguely, done to his instead of just the usual after effects dialogue of 'it runs better'. i'm curious what specific things are referred to as "problems". he also claims he fixes "fueling problems" on the various models. specifically, "Raise rev-limit in all gears to 6600 rpm." for this 1300 model. and it seems that only recently has he put up information that gives more details into what he does with the ECU than had been on his site for a long time. ![]() I will be running the bike more over the week and will provide an update to the review after. (very nice feature of getting the power commander from Ivan' All the maps are already loaded for My setups and future additions. The power commander already has the Maps loaded for an open air intake so i just have to switch over to it once I get one. Hopefully soon I will pick up a Air intake (most likely a cobra Powerflo. I couldn't be happier with the overall performance and responsiveness of the star now. There is no longer any popping during decel. I no longer need to drop a gear to pass with "care". At higher speeds one simply needs to just crack the throttle a bit and the power is there. The acceleration is very smooth through the entire power band. ![]() There is no more "lugging" when twisting the throttle during low speeds. ![]() The throttle response is crisp and very responsive. I have to say "wow" it's like having a different bike. the ride home was approximately 256 Miles. I had a nice long conversation with Ivan and we went over the things that where done to the Bike. I am happy to say I went down and picked up the bike today. Just a little review on Ivan's ECU flash for the V-star 1300. ![]() The light was accurate and quick when sensing motion-it detected cars on a busy street, but we could also adjust it to only detect nearby movement. Even after a heavy storm, there was no damage to the light fixture. (All the mounting hardware comes included in the box.) We also appreciate how durable this mounted solar light is. Installation was a breeze, though you will need a power drill to set up this light. You can also set the motion sensor’s range to as close as 10 feet or as far as 40 feet away. ![]() ![]() While this pick is relatively low profile, it boasts 220 lumens with adjustable brightness, motion sensors, and customizable light durations that allow you to modify how long the lights stay on after detecting motion-anywhere from 10 seconds to four minutes. She also owns a 100 year old house and has spent countless hours finding eco-friendly and money-saving options for upgrading its fixtures.The Maxsa Solar-Powered Dual-Head LED Security Spotlight had a near-perfect performance throughout our testing. Heidi Wachter has been writing about climate and the environment for over a decade. It's a good idea to pick what features are most important to you before you shop, to help narrow down the selection. There are many different features you can find when it comes to motion sensor lights, including different light temperatures, adjustable lighting intervals and brightness settings, and smart technology that can be powered from your phone. Some lights even have customizable sensor ranges, like the LEPOWER 28W Security Lights. However, if you need you light when you're standing further away, it's a good idea to measure your desired distance and check it against the sensor range before you buy. If you just want a light to be triggered when you're close enough to unlock a door, you may not need a very long sensor range. Some lights, like the Leonlite LED Outdoor Security Flood Light (our pick for Best Floodlight), allow you to adjust the angle of the light's beam, so you can angle it exactly where you want it to go. Select a model that offers the appropriate type of light that adequately covers the square footage (typically 75 to 100 square feet) you want to brighten, like walkways to your front and back door, driveways, patios, decks, or hazardous locations like swimming pools and staircases. The big advantage of hard-wired lights is that they have the reliable power source, unless the electricity goes out. Hard-wired lights have the most up-front installation considerations, because you'll have to access your home's circuits and you may want to hire a licensed electrician. Battery-powered lights are also easy to install, but do require the extra work of changing the batteries periodically. We like that solar lights are easy to install and run on clean energy, but you need to make sure that they're placed in a sunny spot in order to full charge. Motion sensor lights are powered three different ways: built-in solar panels, batteries, or hard wired to your home's electrical system. What to Consider When Shopping for Motion Sensor Lights Want enhanced security? Let Ring’s floodlight-camera combo be your eye in the night sky. ![]() If you’re looking for a durable, wireless, solar option, Baxia Technology makes a great all-around, affordable choice. There are energy efficient outdoor lighting options for just about any situation. ![]() Now that you’ve learned the most important aspects of lettering tattoos, it will make the overall design process easier. Everything might look perfect on paper, but as many people learn the hard way, the reality is that tattooing on skin involves a lot of variables and can have a different outcome than what you were expecting. This is another important step to discuss with your tattoo artist. A lettering tattoo too big or too small can affect legibility and take away from the design. You’ll want to scale the size depending on what the message says, how it looks with the font you chose, and where you will be placing the tattoo on your body. If it’s for personal use, check the terms of your chosen font.Īfter selecting the best tattoo font for you, it’s important to consider the size of the letters. One final point to remember: if you’re working on a tattoo project for commercial use, make sure you’re using a free font or you’ve paid the fee involved. It’s also important to discuss the font with your tattoo artist, to ensure the font and the ink will work well together. You might think you’ve nailed it with a handwriting font, for instance, but once that’s applied to skin it might not flow exactly as it does on paper or on screen. Picking the wrong font can throw the whole vibe off. ![]() Just because you like how a font looks, doesn’t mean your message will look good in that font. When choosing a font, consider what the message says, how long it is, and what mood you want to elicit with your lettering tattoo. It’s also the fun part where you get to personalize your tattoo in your own way. But again, always be sure to check the meaning matches your intentions.Ĭhoosing the best tattoo font is a critical decision in the tattoo design process. You can even include glyphs or numerals, if you fancy something a little more esoteric in tone. You never know how much context and nuance might matter. If you choose to get a lettering tattoo in another language, be sure to confirm the content and spelling from native speakers of that language. Whether it’s the name of a loved one or a famous quote, you should make a conscious, well-thought-out decision about what exactly you’re inking on your body. In most cases, you want others to see your design and understand what they are looking at. The contents of your tattoo are also crucial. Make sure to check, double-check, triple-check, and have another set of eyes take a look before you permanently tattoo a mistake and it’s too late. When it comes to getting a permanent lettering tattoo, there is nothing worse than a misspelling or incorrect grammar. ![]() So, what exactly should you consider when getting a lettering tattoo?Ĭorrect spelling and grammar are arguably the most essential things to ensure when getting inked. When done properly, they can be beautiful in design and message. Whether it’s a name, date, or a sentimental word (or phrase), lettering tattoos allow you to display your message in a bold, direct way. ![]() Lettering tattoos are a hugely popular choice when it comes to tattoo designs. It is a tattoo design that uses uppercase or lowercase letters and numbers. A lettering tattoo means exactly what it sounds like. ![]() The principal drawback of these approaches is the rapid viability decay in cells isolated from primary samples for direct cytotoxicity evaluation 12, and the extensive timing of weeks/months to generate representative ex vivo models being incompatible with urgent clinical decisions. However, recent functional assays have emerged to guide cancer treatment these include organoids, patient-derived xenografts or organotypic tissue slices 9, 10, 11, paving the way for functional precision medicine. But these analyses have been mostly used for research purposes and have not significantly impact clinical practice yet. Different cell-based methods including cell viability, colony formation, cytotoxicity, or cell death measurements, among others, have been historically used on patient-derived cell lines to find effective therapies. ![]() Moreover, data acquisition is expensive, time-consuming and produces large datasets that are difficult to process at the hospital in a timely manner 7.Īn alternative approach for personalized cancer treatment is to directly evaluate treatments on patient-isolated cells, overcoming the molecular complexity of individual tumors 8. While multiple successful examples using this approach have been reported 5, most tumors are not driven by a unique mutation and they often adapt to therapy, so they are difficult to eliminate with this strategy 6. In fact, many personalized treatment initiatives explore tumor mutations as biomarkers to assign targeted therapies 4. Using sophisticated molecular analyses and ‘omic’ technologies (i.e., genomics, transcriptomics, proteomics, or metabolomics) clinicians can now identify precise targets and assign specific treatments 2, matching the right drug to every patient 3. With the development of novel anticancer agents and biomarkers, precision medicine was introduced to treat cancer patients. Based on available biomarkers, such as age, type of tumor, stage of development and clinical history, and other information, they stratify patients and assign therapy according to the approved protocols 1. When treating cancer patients, medical oncologists aim to identify the optimal treatment. In summary, this new technology could represent an important advance for precision medicine by providing a fast, easy-to-use and scalable microfluidic device to perform DBP in situ as a routine assay to identify the best treatment for cancer patients. We then validated ♝BP on a refractory GIST patient sample and identified that the combination of dactolisib and venetoclax increased apoptotic priming. We first examined this new technology’s predictive capacity using gastrointestinal stromal tumor (GIST) cell lines, by comparing imatinib sensitive and resistant cells, and we could detect differences in apoptotic priming and anticipate cytotoxicity. We used microfluidic chips to generate a gradient of BIM BH3 peptide, compared it with the standard flow cytometry based DBP, and tested different anticancer treatments. To solve this problem, we developed an innovative microfluidic-based DBP (♝BP) device that overcomes tissue limitations on primary samples. This predictive functional assay presents multiple advantages but a critical limitation: the cell number requirement, that limits drug screening on patient samples, especially in solid tumors. DBP uses synthetic BH3 peptides to measure early apoptotic events (‘priming’) and anticipate therapy-induced cell death leading to tumor elimination. Among these new technologies, dynamic BH3 profiling (DBP) has emerged and extensively been used to predict treatment efficacy in different types of cancer. ![]() Precision medicine is starting to incorporate functional assays to evaluate anticancer agents on patient-isolated tissues or cells to select for the most effective. Evolution and propagation Internet memes propagate in a similar pattern to infectious disease, as shown by this SIR model. Lastly, a meme's longevity was described as essential for a meme's ongoing transmission and evolution. the various pop culture-referencing renditions of the Star Wars Kid viral video), and anomalous juxtaposition (e.g. the comically translated video game line " All your base are belong to us"), intertextuality (e.g. Fecundity was postulated to be determined by three main characteristics: humour (e.g. It was found that the fidelity of internet memes was better understood as replicability, as memes, though preserving their essence, are often not transmitted entirely "intact" (due to remixing of some sort). Ī study by Michele Knobel and Colin Lankshear explored three characteristics of successful memes identified by Richard Dawkins (fidelity, fecundity, and longevity) with Internet memes. Other memes, in contrast, have broader cultural relevance and can be understood even by those outside the subculture one would associate with the meme. Memes can involve in-jokes within online communities, which communicate exclusive cultural knowledge unbeknown to general users through this, a collective group identity can be built. This gives new meaning to the scene from the music video and blends the political and cultural aspects of two different nations. For example, a meme may combine United States politician Mitt Romney's assertion of the phrase " binders full of women" from a 2012 US presidential debate with the Korean pop song " Gangnam Style" by overlaying the text "my binders full of women exploded" onto a frame from Psy's music video where paper blows around him. Intertextuality may be demonstrated through memes that combine different subjects or aspects of culture. Remix uses the original material of the meme but alters it in some way using technology-based manipulation (such as Photoshop). Mimicry refers to the reproduction of a meme in a different setting to the original (e.g., different people imitating the " Charlie Bit My Finger" viral video). The former refers to the tendency of a popular meme to become subject to parody and imitation, which may occur by mimicry or remix. Two central attributes of Internet memes are creative reproduction and intertextuality. For example, they often serve as simply light entertainment, but can also be powerful tools for self-expression, connection, social influence, and political subversion. ![]() There is no single format that memes must follow, and they can have various purposes. Internet memes are also seen as less conceptually abstract compared to their traditional counterpart. ![]() Though the terms are related, Internet memes differ in that they are often short-lasting fads, while traditional memes have their success determined by longevity. ![]() On the Internet, this spread occurs through online mediums such as social media. Internet memes come from the original concept of memes as an element of culture passed on from person to person. Although some argue memes deserve fair use protection, use of media from pre-existing works can sometimes lead to issues with copyright. They appear in a range of contexts, such as marketing, economics, finance, politics, social movements, religion, and healthcare. Memes are considered an important part of Internet culture, and have become a developed research area. More recent genres include "dank" and surrealist memes, as well as short-form videos such as those uploaded on Vine and TikTok. With the rise of social media platforms such as YouTube, Twitter, Facebook, and Instagram, memes have become more diverse and can spread quickly. Mike Godwin coined the term Internet meme in 1993 when he discussed memes as spreading via messageboards, Usenet groups, and email. The name is from the concept of memes proposed by Richard Dawkins in 1972. Characteristics of memes include their susceptibility to parody, their use of intertextuality, their propagation in a viral pattern, and their evolution over time. Internet memes can take various forms, such as images, videos, GIFs, and various other viral sensations. ![]() An Internet meme, or simply meme ( / m iː m/, MEEM), is a cultural item (such as an idea, behaviour, or style) that is spread via the Internet, often through social media platforms. |
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